Science Advances

Supplementary Materials

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  • Fig. S1. Skeletal phenotype of Cas cKO mice is not distinct at birth.
  • Fig. S2. Bone formation parameters are not significantly altered in Cas cKO mice.
  • Fig. S3. Mechanical regulation of bone formation in control and Cas cKO mice and nuclear distribution of Cas in their osteocytes.
  • Fig. S4. ChIP analysis of RelA binding to the RANKL promoter region and measurement of intracellular ROS level.
  • Fig. S5. Cas suppresses RelA acetylation at Lys310 in the nucleus and alleviates NF-κB activity without requiring phosphorylation of its substrate domain.
  • Fig. S6. Cas672-738 contains the region responsible for the inhibition of NF-κB activity.
  • Fig. S7. Neither bone mass of mice with intact Cas alleles nor bone formation of Cas cKO mice is significantly altered by heterozygous deletion of Rela in osteocytes (Rela cKO).

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