Science Advances

Supplementary Materials

The PDF file includes:

  • Fig. S1. Mean coverage of the coding regions of CSDE1 in ExAC whole-exome sequencing data.
  • Fig. S2. Correlations of the two independent HITS-CLIP experiments and pathway enrichment of Csde1-binding targets.
  • Fig. S3. Time-spatial expression pattern of CSDE1 in human and mouse brain.
  • Fig. S4. CSDE1 disruptive mutations show loss of function.
  • Fig. S5. Interfere efficiency of two shRNA in neurons.
  • Fig. S6. Immunoblotting with anti-dUnr antibodies was performed to examine the expression level of dUnr in dunr, dunr/Df1, dunr/Df2, and Da-RNAi lines.
  • Fig. S7. Overexpression of dUnr or hCSDE1 has no effect on both bouton number and satellite bouton number compared to WT controls.

Download PDF

Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Detailed clinical information for probands or carrier patients with LGD mutation or de novo missense mutations.
  • Table S2 (Microsoft Excel format). Validation result of selected RNA binding targets.
  • Table S3 (Microsoft Excel format). High-confidence RNA binding targets called by two software programs in two experiments.

Files in this Data Supplement: