Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. Proof of similarity for degradable and nondegradable P(AAm-co-MAA) nanogels.
  • Fig. S2. Nanogel swelling and degradation analysis with QCM.
  • Fig. S3. FTIR analysis of N,N-dimethylethylenediamine– or tyramine-conjugated nanogels.
  • Fig. S4. Potentiometric titration analysis of DMOD and TMOD nanogels.
  • Fig. S5. Full data of pH-responsive, modified nanogel swelling, including data for aggregated nanogels.
  • Fig. S6. Methylene blue loading in DMOD and TMOD nanogels.
  • Fig. S7. Nanogel cytotoxicity to murine fibroblasts, as determined by MTS and LDH assays.
  • Fig. S8. Cytotoxicity of degradable, nondegradable, and degraded nanogels to fibroblasts, macrophages, and colon epithelial cells.
  • Fig. S9. Cytotoxicity of fluorescent TMOD, DMOD, or unmodified (Fluor) nanogels.
  • Fig. S10. Representative images for dose-response and kinetic nanogel uptake.

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