Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. Characterization of the as-synthesized NPs.
  • Fig. S2. Cytotoxicity evaluation of MCF-7 cells with NIR irradiation at different times.
  • Fig. S3. Stability test of self-assembled nanostructures.
  • Fig. S4. Cellular uptake and intracellular distribution of NPs.
  • Fig. S5. C-myc mRNA level determined in cytoplasm and nucleus separately by real-time PCR.
  • Fig. S6. Safety evaluation of the nanosunflower structure.
  • Fig. S7. Penetration behavior study of fluorescein isothiocyanate–labeled nanosunflowers in multicellular spheroid model.
  • Fig. S8. Quantitative biodistribution of average Au content in tissues including the heart, liver, spleen, lung, kidney, and tumor after different treatments.
  • Table S1. Hydrodynamic size distribution of Au-POY2T NPs and nanosunflowers before and after NIR irradiation for 3, 10, 12.5, or 15 min, respectively.
  • Table S2. Histopathological scoring results of the H&E staining images.

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