Science Advances

Supplementary Materials

This PDF file includes:

  • Supplementary Materials and Methods
  • Supplementary Text
  • Fig. S1. Free CRADLE/White Eye Detector application for iOS or Android.
  • Fig. S2. Examples of pathologic leukocoria detection by CRADLE in photographs with low pupil resolution.
  • Fig. S3. Comparison of photography angle and detection of pathologic leukocoria by CRADLE.
  • Fig. S4. Longitudinal frequency and detection of physiologic leukocoria among 29,734 photographs of 20 control children using the iPhone X smartphone.
  • Fig. S5. Longitudinal frequency and detection of physiologic leukocoria among 29,734 photographs of 20 control children using the iPhone 7 smartphone.
  • Fig. S6. Longitudinal frequency and detection of physiologic leukocoria among 29,734 photographs of 20 control children using the Google Pixel 2XL smartphone.
  • Fig. S7. Longitudinal frequency and detection of pathologic leukocoria in childhood photographs of 20 test children with eye disease using the iPhone 7 smartphone.
  • Fig. S8. Longitudinal frequency and detection of pathologic leukocoria in childhood photographs of 20 test children with eye disease using the Google Pixel 2XL smartphone.
  • Fig. S9. Effect of image resolution on classification of leukocoric eye by CRADLE using the iPhone X smartphone.
  • Fig. S10. Average HSV coordinates of leukocoric pupils from test and control children.
  • Table S1. Personalized detection rates of pathologic leukocoria by CRADLE (iPhone 7) among 23,248 photographs of 20 test children with retinoblastoma, Coats’ disease, cataract, anisometropic amblyopia, and hyperopia.
  • Table S2. Personalized detection rates of pathologic leukocoria by CRADLE (Google Pixel 2XL) among 23,248 photographs of 20 test children with retinoblastoma, Coats’ disease, cataract, anisometropic amblyopia, and hyperopia.
  • Table S3. Personalized detection rates of physiologic leukocoria by CRADLE (iPhone 7) among photographic libraries of 20 control children.
  • Table S4. Personalized detection rates of physiologic leukocoria by CRADLE (Google Pixel 2XL) among photographic libraries of 20 control children.
  • Table S5. Sensitivity, specificity, and accuracy of CRADLE (iPhone 7) for detecting pathologic leukocoria in childhood photographs.
  • Table S6. Sensitivity, specificity, and accuracy of CRADLE (Google Pixel 2XL) for detecting pathologic leukocoria in childhood photographs.
  • Table S7. Personalized detection rates of pathologic leukocoria by CRADLE (iPhone X) among 23,248 photographs of 20 test children with retinoblastoma, Coats’ disease, cataract, anisometropic amblyopia, and hyperopia.
  • Table S8. Personalized detection rates of physiologic leukocoria by CRADLE (iPhone X) among photographic libraries of 20 control children.
  • Table S9. Example of a data sheet used to obtain intrinsic detection rates from test and control children.
  • Table S10. Linear ranking matrix used to assign a single outcome to a photograph containing two pupils (based on the occurrence of the highest rank of order: ITP > IFN > IFP > ITN).
  • Table S11. Camera make and model used to capture photographs of test and control children (extracted from metadata).
  • References (5355)

Download PDF

Files in this Data Supplement: