Science Advances

The PDF file includes:

• Section S1. Assumptions made in the kinetic model
• Section S2. Cooperativity without allostery
• Section S3. Overview of all kinetic diagrams
• Section S4. Differentiating between aggregates and recruited assemblers
• Section S5. Residuals obtained for the simulated annealing fit algorithm
• Fig. S1. Determining the reaction order of free assembly.
• Fig. S2. Template occupancy profiles for simulations with a rigid template.
• Fig. S3. Overview of kinetic diagrams at varying assembler-template interaction strengths without allostery.
• Fig. S4. Overview of kinetic diagrams at varying assembler-assembler interaction strengths without allostery.
• Fig. S5. Overview of kinetic diagrams at varying assembler-assembler interaction strengths including allostery.
• Fig. S6. Schematic representation of two free-assembled (FA) states.
• Fig. S7. Overview of kinetic diagrams at varying assembler-assembler interaction strengths without allostery, differentiating between two FA states.
• Fig. S8. Overview of kinetic diagrams at varying assembler-assembler interaction strengths including allostery, differentiating between two FA states.
• Fig. S9. Histograms of fit residuals at varying assembler-template interaction strength.
• Fig. S10. Histograms of fit residuals at varying assembler-assembler interaction strength.
• References (40–46)

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Other Supplementary Material for this manuscript includes the following:

• Movie S1 (.mp4 format). Time lapse of a simulation in the absence of allostery.
• Movie S2 (.mp4 format). Time lapse of a simulation including allostery.