Science Advances

Supplementary Materials

The PDF file includes:

  • Section S1. Assumptions made in the kinetic model
  • Section S2. Cooperativity without allostery
  • Section S3. Overview of all kinetic diagrams
  • Section S4. Differentiating between aggregates and recruited assemblers
  • Section S5. Residuals obtained for the simulated annealing fit algorithm
  • Fig. S1. Determining the reaction order of free assembly.
  • Fig. S2. Template occupancy profiles for simulations with a rigid template.
  • Fig. S3. Overview of kinetic diagrams at varying assembler-template interaction strengths without allostery.
  • Fig. S4. Overview of kinetic diagrams at varying assembler-assembler interaction strengths without allostery.
  • Fig. S5. Overview of kinetic diagrams at varying assembler-assembler interaction strengths including allostery.
  • Fig. S6. Schematic representation of two free-assembled (FA) states.
  • Fig. S7. Overview of kinetic diagrams at varying assembler-assembler interaction strengths without allostery, differentiating between two FA states.
  • Fig. S8. Overview of kinetic diagrams at varying assembler-assembler interaction strengths including allostery, differentiating between two FA states.
  • Fig. S9. Histograms of fit residuals at varying assembler-template interaction strength.
  • Fig. S10. Histograms of fit residuals at varying assembler-assembler interaction strength.
  • References (4046)

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.mp4 format). Time lapse of a simulation in the absence of allostery.
  • Movie S2 (.mp4 format). Time lapse of a simulation including allostery.

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