Science Advances

Supplementary Materials

This PDF file includes:

  • Supplementary Materials and Methods
  • Fig. S1. Phenotype of Cxxc1 conditional KO mice.
  • Fig. S2. Analysis of T cell differentiation in vitro from WT and Cxxc1-deficient mice.
  • Fig. S3. Phenotype of RORγtcreCxxc1wt/wt and RORγtcreCxxc1fl/fl mice.
  • Fig. S4. Cxxc1 deficiency restricts T cell–mediated autoimmunity.
  • Fig. S5. Cxxc1 deficiency increased sensitivity to C. rodentium infection.
  • Fig. S6. Cxxc1 regulates TH17 differentiation with its H3K4me3 function.
  • Fig. S7. Genome-wide maps of Cxxc1 binding and H3K4me3 modifications in TH17 cells differentiated from naive CD4+ T cells with TGF-β1 and IL-6 for 24 hours.
  • Fig. S8. The IL-6–Stat3 signaling pathway was defective after Cxxc1 deletion.
  • Fig. S9. Cxxc1 mediates TH17 cell differentiation by mediating IL-6Rα expression.
  • Table S1. Down regulated genes in Cfp1 deficient Th17 cells.

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