Science Advances

This PDF file includes:

• Table S1. Participant demographic and smoking characteristics.
• Table S2. Task effect cluster coordinates.
• Table S3. Group effect cluster coordinates.
• Table S4. Drug effect cluster coordinates across all participants.
• Table S5. Drug effect cluster coordinates among smokers.
• Fig. S1. Anatomically defined habenula location across all participants.
• Fig. S2. Task effect: Whole-brain RESPONSE * FEEDBACK interaction analysis.
• Fig. S3. A priori composite mask of interest.
• Fig. S4. Group effects: Additional characterization of regions showing smoker versus nonsmoker differences in feedback responsivity.
• Fig. S5. Drug effect: Pharmacologically induced alterations following both positive (iC) and negative (iE) feedback across all sessions for the two participant groups (smokers and nonsmokers).
• Fig. S6. Drug-effects: ROI-based analyses using anatomically defined left and right habenula locations to assess nicotine-induced alterations following both positive (iC) and negative (iE) feedback.
• Fig. S7. Drug effects: Additional characterization of regions showing nicotine-induced alterations.

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