Science Advances

Supplementary Materials

This PDF file includes:

  • Table S1. Participant demographic and smoking characteristics.
  • Table S2. Task effect cluster coordinates.
  • Table S3. Group effect cluster coordinates.
  • Table S4. Drug effect cluster coordinates across all participants.
  • Table S5. Drug effect cluster coordinates among smokers.
  • Fig. S1. Anatomically defined habenula location across all participants.
  • Fig. S2. Task effect: Whole-brain RESPONSE * FEEDBACK interaction analysis.
  • Fig. S3. A priori composite mask of interest.
  • Fig. S4. Group effects: Additional characterization of regions showing smoker versus nonsmoker differences in feedback responsivity.
  • Fig. S5. Drug effect: Pharmacologically induced alterations following both positive (iC) and negative (iE) feedback across all sessions for the two participant groups (smokers and nonsmokers).
  • Fig. S6. Drug-effects: ROI-based analyses using anatomically defined left and right habenula locations to assess nicotine-induced alterations following both positive (iC) and negative (iE) feedback.
  • Fig. S7. Drug effects: Additional characterization of regions showing nicotine-induced alterations.

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