Science Advances

Supplementary Materials

The PDF file includes:

  • Fig. S1. MIBI-TOF is structurally designed for high-throughput, highly multiplexed imaging with high sensitivity and low noise.
  • Fig. S2. Thirty-six–plex staining using MIBI-TOF.
  • Fig. S3. MIBI-TOF can sensitively image across the elemental spectrum and allows customized ion dose/area to detect antigens with varying abundances.
  • Fig. S4. Evaluation of observed and expected regional distribution of tumor and immune subtypes within a single patient.

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Sensitivity measurements.
  • Table S2 (Microsoft Excel format). Imaging conditions.
  • Table S3 (Microsoft Excel format). Tissues and antibodies.
  • Movie S1 (.mov format). Depth profile of melanoma.

Files in this Data Supplement: