Science Advances

Supplementary Materials

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  • Fig. S1. Reaching movements are goal directed after 60 days of training.
  • Fig. S2. Optogenetic activation of PV inhibitory neurons inactivates cortex.
  • Fig. S3. Task performance and movements in light-off trials in head-bar control versus M1 inactivation days are generally equivalent.
  • Fig. S4. M1 inactivation effects are reduced in the later learning stages compared to the early stage, even in mice without a prior experience of early-stage inactivation.
  • Fig. S5. Licking variability does not explain the longitudinal changes in M1 activity consistency.
  • Fig. S6. The fraction of movement-related neurons and their activity level also change over the course of long-term learning.

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