Science Advances

Supplementary Materials

The PDFset includes:

  • Fig. S1. Representative images of the slow dissolution of an MN patch with PVA/sucrose backing (i.e., noneffervescent) in PBS over time.
  • Fig. S2. Local effects of an effervescent MN patch for LNG delivery on rat skin in vivo.
  • Fig. S3. Assessment of reported pain during MN patch administration scored by participants on a visual analog scale of 0 (no pain) to 10 (pain of a hypodermic injection).
  • Fig. S4. Percentage of participants showing preference for self-administration or doctor administration for future application of an effervescent MN patch for long-acting contraception.
  • Table S1. Pharmacokinetic parameters of LNG following administration of effervescent MN patch containing LNG.
  • Table S2. Summary of the prevalence of skin reactions at different time points after the application of effervescent MN patches to human participants.

Download PDF

Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.avi format). Separation of MNs from effervescence backing in PBS solution.
  • Movie S2 (.avi format). Separation of MNs from noneffervescence backing in PBS solution.

Files in this Data Supplement: