Science Advances

Supplementary Materials

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  • Fig. S1. The molecular weight of α-TNF was increased by CBP conjugation.
  • Fig. S2. The target and sequence specificity of CBP.
  • Fig. S3. Distribution of CBP–α-TNF to organs and tissues in the arthritis model.
  • Fig. S4. CBP–α-TNF reduces macrophages and neutrophils within the paws.
  • Fig. S5. Effect of subcutaneous injection of CBP–α-TNF in the arthritis model.
  • Fig. S6. Short-term safety study of CBP–α-TNF in the arthritis model.
  • Fig. S7. CBP conjugation provided collagen affinity to α–TGF-β.

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