Science Advances

Supplementary Materials

This PDF file includes:

  • Table S1. Characteristics of patients.
  • Table S2. The predicted binding free energy components for the ALX/FPR2-RvDp5 and ALX/FPR2-LXA4 complexes using the MM/PBSA method.
  • Fig. S1. Inflammation profiles in SL versus DR inflammation.
  • Fig. S2. Fgl2 expression is regulated by miR-466l and metalloproteinases.
  • Fig. S3. Deficiency of Fgl2 promotes inflammation initiation and delays resolution.
  • Fig. S4. Fgl2 deficiency reduces RvDp5 production.
  • Fig. S5. Fgl2 regulates PMN apoptosis and phagocytes of MΦs.
  • Fig. S6. An overview of binding modes for the four isomers of RvDp5 and LXA4 in the binding pocket of ALX/FPR2.
  • Fig. S7. RvDp5 modulates Fgl2 and improves sepsis survival.

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Correction (5 February 2020): In a previous version, the chemical structures of RvD1 and RvD2 were incorrect. Additionally, the double bonds in Figure S6A were configured incorrectly. This article has been updated with a corrected figure and corrected chemical structures.

The original version is accessible here.

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