Science Advances

Supplementary Materials

The PDFset includes:

  • Supplementary Materials and Methods
  • Fig. S1. Structural information on MBD2 and c-Myc.
  • Fig. S2. SEA and cell migration analysis for the nine selected hit compounds targeting MBD2.
  • Fig. S3. MD simulations of the selected compound-docked structures of MBD2 and c-Myc.
  • Fig. S4. FRET dynamics of ABA and APC to the MBD2-p66α interaction.
  • Fig. S5. Effects of ABA and APC on the expression of EMT markers and CSC properties in various breast and colon cancer cells.
  • Table S1. Molecular docking result (H-bond, hydrogen bond; N/A, not available).
  • Table S2. Selection of compound by in silico assessment of off-target probability by SEA analysis.
  • Table S3. Backbone torsion angle variations (95% confidence interval) of the four key residues in the four different MD simulations of MBD2.
  • Table S4. T test and P values on the backbone torsion angle summarized in table S3.
  • Table S5. Primer sets for vector construction.
  • References (4669)

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