Science Advances

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• Fig. S1. Functional loss of NPR-8 enhances C. elegans survival against pathogen infection and increases pathogen clearance from the intestine.
• Fig. S2. NPR-8 functions in AVL and DVB neurons to regulate defecation but not survival against infection.
• Fig. S3. NPR-8 does not play a role in conserved innate immune pathways.
• Fig. S4. NPR-8–regulated collagen genes are involved in C. elegans defense and defecation.
• Fig. S5. NPR-8 regulates collagen expression in the cuticle and hypodermis and controls the dynamics of cuticle structure in response to infection.
• Fig. S6. NPR-8 is expressed in amphid sensory neurons and throughout developmental stages.
• Fig. S7. NPR-8 is not involved in bacteria sensing, as determined by food choice assays.
• Table S1. Differential expression of genes in conserved innate immune pathways in npr-8(ok1439) animals relative to wild-type animals exposed to P. aeruginosa.
• Table S2. Ontology analyses of up-regulated genes in P. aeruginosa–infected wild-type animals relative to uninfected controls or in uninfected npr-8(ok1439) animals relative to wild-type animals.
• Table S3. List of transgenic C. elegans strains generated in this study.

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