Science Advances

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• Fig. S1. HEDGES hG-CSF cDNA injection elicits the production of endogenous mouse anti–hG-CSF antibodies.
• Fig. S2. Intravenous HEDGES injection of the human TP53 cDNA is expressed predominantly in mouse VECs.
• Fig. S3. Intravenous injection of HEDGES vector DNA does not detectably integrate into genomic DNA of injected mice.
• Fig. S4. HEDGES treatment with a β-GAL reporter-containing plasmid results in expression of reporter in CD31⁺CD45⁻ lung cells in mice.
• Fig. S5. Development of mouse anti-rituximab antibodies suppresses rituximab levels in HEDGES-treated mice.
• Table S1. HEDGES expression plasmids.

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