Science Advances

Supplementary Materials

The PDFset includes:

  • Fig. S1. BAZ1B KD validation in iPSC-derived NCSCs and evaluation of its impact on NCSC migration.
  • Fig. S2. BAZ1B KD affects the transcriptome of iPSC-derived NCSCs.
  • Fig. S3. Generation of BAZ1B-FLAG iPSC lines and differentiation to NCSCs.
  • Fig. S4. BAZ1B KD induces a significant chromatin remodeling at distal regions.
  • Text S1A. Detailed description of HOMER motif enrichments performed on BAZ1B ChIP-seq data.
  • Text S1B. List of key direct targets of BAZ1B involved in neural- and NC-related development and relevant associated literature.
  • Table S1. Genes relevant for NC and NC-derived features whose expression follows BAZ1B levels.
  • Table S3. Crucial genes identified in the overlap between BAZ1B datasets and archaic versus modern human datasets reported in this study.
  • Table S4. Alternative differential expression analysis functions tested with iPSCpower to assess the efficacy of our design matrix (~individual+BAZ1B). R code provided.
  • Table S5. Number of genes differentially expressed following BAZ1B data in our numerical analysis compared to an analysis conducted on randomized HipSci data, using Edg2 function (see table S4).
  • References (6189)

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Other Supplementary Material for this manuscript includes the following:

  • Table S2A (Microsoft Excel format). Significant genes in human evolution.
  • Table S2B (Microsoft Excel format). Regulatory excess in archaic humans, overlap with BAZ1B targets.
  • Table S2C (Microsoft Excel format). Mutation excess in archaic humans, overlap with BAZ1B targets.
  • Table S2D (Microsoft Excel format). Regulatory changes (exclusive) in archaic humans, overlap with BAZ1B targets.
  • Table S2E (Microsoft Excel format). Missense mutations in archaic humans, overlap with BAZ1B targets.
  • Table S2F (Microsoft Excel format). Mutation excess in archaic humans corrected for length, overlap with BAZ1B targets.
  • Table S2G (Microsoft Excel format). Regulatory excess in modern humans, overlap with BAZ1B targets.
  • Table S2H (Microsoft Excel format). Mutation excess in modern humans, overlap with BAZ1B targets.
  • Table S2I (Microsoft Excel format). Regulatory changes (exclusive) in modern humans, overlap with BAZ1B targets.
  • Table S2J (Microsoft Excel format). Missense mutations in modern humans, overlap with BAZ1B targets.
  • Table S2K (Microsoft Excel format). Mutation excess in modern humans corrected for length, overlap with BAZ1B targets.
  • Table S2L (Microsoft Excel format). Genes under positive selection in domesticated animals, overlap with BAZ1B targets.
  • Table S2M (Microsoft Excel format). Genes under positive selection from Peyrégne et al. (13) in modern humans, overlap with BAZ1B targets.
  • Table S2N (Microsoft Excel format). Genes under positive selection from Racimo (14) in modern humans, overlap with BAZ1B targets.

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