Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. trap-1 mutant DNA sequences and predicted effects on TRAP-1 protein.
  • Fig. S2. trap-1 and Y71F9AL.1 mutant phenotypes.
  • Fig. S3. Alignment of C. elegans TRAP-1 and human TRAPα amino acid sequences.
  • Fig. S4. Dauer-defective phenotypes of a trap-1 null mutation.
  • Fig. S5. Effect of reduced TRAPα activity on preproinsulin, proinsulin, and insulin levels in INS 832/13 cells.
  • Fig. S6. Reexpression of TRAPα in TRAPα KO cells rescues insulin production in a dose-dependent manner.
  • Table S1. Description of eight daf-2/InsR alleles assayed in fig. S5A.

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