Science Advances

Supplementary Materials

The PDFset includes:

  • Fig. S1. Mice with T cell–specific ablation of the miR-23~27~24 family exhibited enhanced TFH and GC B cell responses during airway allergic reaction.
  • Fig. S2. Elevation in the frequency of TFH cells in the LCMV-specific T cell population upon LCMV infection.
  • Fig. S3. Enhanced LCMV-specific Ab responses in mice with T cell–specific ablation of the miR-23~27~24 family.
  • Fig. S4. TFH cell–intrinsic role of the miR-23~27~24 family in regulating TFH cell responses.
  • Fig. S5. Elevated expressions of the miR-23~27~24 family in GC-TFH cells.
  • Fig. S6. Treg cell–specific ablation of the miR-23~27~24 family led to any alteration in TFH and GC B cell responses upon LCMV infection.
  • Fig. S7. Exaggerated regulation by the miR-23~27~24 family in T cells led to reduced TFH cell responses.
  • Fig. S8. Presence of distinct T cell subsets in mice during LCMV infection.
  • Fig. S9. TOX was repressed by miR-23 and miR-27 but not miR-24.
  • Fig. S10. TOX knockdown led to impaired TFH cell responses.
  • Fig. S11. Modulations of TOX amounts in T cells did not affect T cell homeostasis.
  • Fig. S12. Id2, Icos, and Maf are not regulated by TOX in TFH cells.

Download PDF

Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Gene list III: Genes are significantly up-regulated in both TFH and GC-TFH cells.
  • Table S2 (Microsoft Excel format). Gene list IV: Genes are significantly up-regulated in TFH cells.
  • Table S3 (Microsoft Excel format). Gene list V: Genes are significantly up-regulated in GC-TFH cells.
  • Table S4 (Microsoft Excel format). Gene list I: Genes are significantly up-regulated in T-DKO GC-TFH cells.
  • Table S5 (Microsoft Excel format). Gene list II: Genes are significantly up-regulated in T-DKO TFH cells.
  • Table S6 (Microsoft Excel format). miR-23 targets by HITS-CLIP.
  • Table S7 (Microsoft Excel format). miR-24 targets by HITS-CLIP.
  • Table S8 (Microsoft Excel format). miR-27 targets by HITS-CLIP.
  • Table S9 (Microsoft Excel format). Gene list: Common elements in “GSE93804” and “GSE65850.”.
  • Table S10 (Microsoft Excel format). Primer list.

Files in this Data Supplement: