Science Advances

Supplementary Materials

The PDFset includes:

  • Fig. S1. DOX does not cause pathology in parental myoblasts.
  • Fig. S2. Inhibition of caspase-3/7 or ROS does not prevent C1QBP mislocalization.
  • Fig. S3. Compounds can provide resistance to DUX4-induced toxicity.
  • Fig. S4. DOX does not cause nuclear pathologies in parental myoblasts.
  • Fig. S5. FUS aggregates localize to sites of dsDNA breaks and are inhibited by 4MU.
  • Fig. S6. DNA damage does not cause accumulation of dsRNA after 24 hours and depends on 4MU.
  • Fig. S7. ╬▓ME does not prevent DUX4-induced appearance of dsRNA foci.
  • Table S1. Cells used in this study.
  • Table S2. Primers used in this study.
  • Legend for data S1

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Other Supplementary Material for this manuscript includes the following:

  • Data S1 (Microsoft Excel format). Identification of DUX4 copurifying proteins by mass spectrometry.

Files in this Data Supplement: