Science Advances

Supplementary Materials

The PDFset includes:

  • Fig. S1. Modest gene expression alterations in DNMT3L matKO morulae.
  • Fig. S2. Characterization of DNA methylome of EED CTR and matKO E6.5 ExE.
  • Fig. S3. Both DNMT3A and DNMT3B contribute to somatic DMR establishment at noncanonical imprinting loci.
  • Fig. S4. Validation of RNA-seq and RRBS datasets of DNMT3A/3B DKO ExE.
  • Fig. S5. H3K27me3 profile in E6.5 ExE.
  • Fig. S6. H3K4me3 profiles in morula and TE.

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). RNA-seq analyses of DNMT3L CTR and matKO morulae.
  • Table S2 (Microsoft Excel format). DNA methylation analyses of EED CTR and matKO E6.5 ExE.
  • Table S3 (Microsoft Excel format). DNA methylation and RNA-seq analyses of DNMT3A/3B DKO E6.5 ExE.
  • Table S4 (Microsoft Excel format). Allelic read counts of promoter H3K4me3 in morula and TE and summary of datasets generated in this study.

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