Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. Vegfa overexpression in the epidermis mediates psoriasis-like disease.
  • Fig. S2. Composition of immune infiltrate.
  • Fig. S3. Nrp1 and Flt1 are genetically linked.
  • Fig. S4. Epidermal autonomous expression of Flt1 is essential for psoriasis development induced by c-Jun/JunB deletion.
  • Fig. S5. Genes presenting AP-1 motifs in the chromatin regions remodeled by Vegfa/Flt1 signaling.
  • Fig. S6. Phosphorylation assay.
  • Fig. S7. Model of the epidermal autonomous VEGF/Flt1/Nrp1 signaling in psoriasis-like disease.
  • Table S1. Biological functions of up-regulated genes in an Nrp1/Flt1-dependent manner.
  • Table S2. Biological function of down-regulated genes in an Nrp1/Flt1-dependent manner.
  • Table S3. Biological function of genes associated with ATAC peaks in an Nrp1/Flt1-dependent manner.

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