Science Advances

Supplementary Materials

The PDFset includes:

  • Fig. S1. AMPARs mediate most of the intracellular Cai2+ responses in primary cultured mature oligodendrocyte somas.
  • Fig. S2. GluA4 expression is selectively reduced in CC1+ cells from PLPcreER+;GluA4fl/fl compared to PLPcreER;GluA4fl/fl mice.
  • Fig. S3. AMPAR subunits GluA1-3 are not changed in adult spinal cord oligodendrocytes from PLPcreER+;GluA4fl/fl compared to PLPcreER;GluA4fl/fl mice.
  • Fig. S4. GluA4 transcript expression is reduced in PLPcreER+;GluA4fl/fl mouse white matter.
  • Fig. S5. Myelin is unaltered in naïve PLPCreER+:GluA4fl/fl mice.
  • Fig. S6. Frequencies of myelin g-ratio and axon diameter are unchanged in naïve PLPCreER+:GluA4fl/fl mice.
  • Fig. S7. TdTomato expression is predominately limited to oligodendrocytes in EAE PLPcreER+;tdTomato+ mice.
  • Fig. S8. The GluA4 AMPAR subunit remains reduced in oligodendrocytes from PLPcreER+;GluA4fl/fl mice subjected to AE.
  • Legends for movies S1 and S2

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.mp4 format). 3D representation of myelin and axons from a PLPcreER;GluA4fl/fl (WT) mouse.
  • Movie S2 (.mp4 format). 3D representation of myelin and axons from a PLPcreER+;GluA4fl/fl (KO) mouse.

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