Science Advances

Supplementary Materials

This PDF file includes:

  • Section S1. CPMC model: Variance of chromatin packing density
  • Section S2. Random medium simulations: Calculation of D from mass density variations
  • Section S3. Calculation of ϕin,0 from ChromEM measurements
  • Fig. S1. Analysis of the relationship between D and σϕin2.
  • Fig. S2. Random medium simulations for low and high D.
  • Fig. S3. CVC distributions of A549 and BJ cells as measured by ChromEM.
  • Fig. S4. Transcriptional malleability in A2780 and M248 cells.
  • Fig. S5. GO analysis of up-regulated genes.
  • Fig. S6. t-SNE transcriptional heterogeneity analysis is independent of seed.
  • Fig. S7. Transcriptional heterogeneity is increased in high D cells.
  • Fig. S8. Relationship between survival time and transcriptional divergence.
  • Table S1. Descriptions and values of CPMC model parameters.
  • Table S2. TCGA patient information.
  • References (6163)

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