Science Advances

Supplementary Materials

This PDF file includes:

  • Supplementary Materials and Methods
  • Fig. S1. AHR homology model.
  • Fig. S2. Conformational analyses of ligands.
  • Fig. S3. Lead optimization for metabolic stability.
  • Fig. S4. Biological characterization of lead compounds in vitro and after oral administration.
  • Fig. S5. Toxicity study of PY109.
  • Fig. S6. Lead compounds attenuate DSS-induced colitis in mice.
  • Fig. S7. Effect of PY109 on Th17 and CMT-93 cells.
  • Table S1. Representative SARs for screening library.
  • Table S2. SARs of pyridine series.
  • Table S3. Pathway analysis for PY109 counter-regulated genes.

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