Science Advances

Supplementary Materials

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  • Fig. S1. Age-dependent NGF and TrkA deficits in the HF and CTX of TgCRND8 mice.
  • Fig. S2. Intraparenchymal injection of D3-induced TrkA-dependent signaling in the basal forebrain of 6-month-old non-Tg mice.
  • Fig. S3. Intraparenchymal injection of NGF-stimulated TrkA signaling pathways in the basal forebrain of 6-month-old non-Tg mice.
  • Fig. S4. MRIgFUS-mediated BBB disruption in the basal forebrain after intravenous administration of PBS or D3.
  • Fig. S5. Increased extravasation of endogenous immunoglobulins into the basal forebrain following MRIgFUS.
  • Fig. S6. MRIgFUS BBB disruption in the basal forebrain did not cause erythrocyte extravasation.
  • Fig. S7. MRIgFUS-BBB disruption in the basal forebrain did not induce neuronal apoptosis.
  • Fig. S8. Western blot analysis of total Akt, MAPK, CREB, and JNK protein levels after MRIgFUS-mediated delivery of D3.
  • Table S1. Primer sequences for qRT-PCR.

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