Science Advances

Supplementary Materials

This PDF file includes:

  • Supplementary Materials and Methods
  • Fig. S1. Analysis of single-cell WGS data from normal human skin and brain cells.
  • Fig. S2. Identification and characterization of CNVs in freshly collected BRCA2mut/+ breast epithelial cells.
  • Fig. S3. Characterization of replication stress response deficiency and haploinsufficiency in BRCA2mut/+ breast epithelial cells.
  • Fig. S4. Suppression of NF-κB/SASP response associated with loss of BRCA2.
  • Fig. S5. Proportions of mammary epithelial cell subsets in BRCA2 carrier and control tissues.
  • Table S1. Characteristics of patients undergoing WGS of breast tissues.
  • Table S2. Summary of single-cell site-specific PCR/sequencing data.
  • Table S3. Characteristics of patients undergoing RNA-seq of breast tissues.
  • Reference (43)

Download PDF

Files in this Data Supplement: