Science Advances

The PDFset includes:

• Fig. S1. CRISPR-Cas9 gene modification strategy is outlined.
• Fig. S2. The SNP in PBANKA_011210 ApiAP2 TF does not interfere with the progression of sexual and pre-erythrocytic stages of the P. berghei life cycle.
• Fig. S3. Flow cytometry gating strategy.
• Fig. S4. Graphs comparing mice infected with PbNK65^F and PbNK65^S.
• Table S1. Summary of changes observed between the WT and CRISPR-Cas9–mutated parasites based on whole-genome sequencing analysis.
• Supplementary information 2. The 900-nucleotide synthetic sequence.

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Other Supplementary Material for this manuscript includes the following:

• Data file S1 (.csv format). Supplementary information 1: DNA binding analysis of ApiAP2 domain 1.