Science Advances

Supplementary Materials

This PDF file includes:

  • Schematic S1. PCa innervation.
  • Fig. S1. Expression of neural laminins in prostate tumor tissues and healthy prostate tissues.
  • Fig. S2. Characterization of Cy7-NP41.
  • Fig. S3. The targeting of NP41 in vivo.
  • Fig. S4. Orthotopic PCa with high and low nerve density constructed by PBS and 6OHDA.
  • Fig. S5. FLI of high and low nerve density of PCa in PBS- or 6OHDA-treated mice.
  • Fig. S6. Orthotopic PCa with high and low nerve density constructed by sham-operated nerve-intact and surgically severed afferent hypogastric nerves.
  • Fig. S7. FLI of high and low nerve density of PCa in sham-operated or surgical HGNx mice.
  • Fig. S8. Acute, subchronic, and chronic toxicity evaluation of PSN NPs after intravenous injection in health mice.
  • Fig. S9. Evaluation of health mice nerve function after PSN NPs systemic administration for six times.
  • Fig. S10. Evaluation of health mice nerve marker expression after PSN NPs systemic administration for six times.
  • Table S1. Correlation between concentration of peptides and optical absorption peak at 280 nm.

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