Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. DENV2 NS2A suppresses RNAi in S2 cells.
  • Fig. S2. DENV2 NS2A has dsRNA-binding activity that is required to suppress Dicer cleavage in vitro.
  • Fig. S3. The analyses of DENV2-derived vsiRNAs in 293T-IFNAR1-KO cells.
  • Fig. S4. VSR deficiency causes replication and infection defects in DENV2-infected mice.
  • Fig. S5. The knockdown of aaDicer2 and aaAGO2 in Aag2 cells and the conserved active site residues among different AGO proteins.
  • Fig. S6. NS2As from the four DENV serotypes suppress RNAi in S2 and Aag2 cells.
  • Fig. S7. Flaviviral NS2As suppress RNAi in 293T cells.
  • Fig. S8. JEV NS2A inhibits antiviral RNAi in both mosquito and human somatic cells.
  • Table S1. Profiles of vsRNAs.
  • Table S2. The primers used in this study.

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