Science Advances

Supplementary Materials

The PDFset includes:

  • Fig. S1. Pluripotency markers are down-regulated in soft substrate.
  • Fig. S2. GO terms highlighting the characteristics of down-regulated genes in the soft substrates compared to that with hard substrates.
  • Fig. S3. Combination of soft substrate and chemical factors enhance the urea production of hPSC-derived hepatocytes.
  • Fig. S4. Most of the differentially regulated lncRNAs show a stiffness-associated expression signature in hPSCs.
  • Fig. S5. Knockdown of lncRNA LINC00458 does not affect pluripotency genes.
  • Fig. S6. The lncRNA LINC00458 does not act in a cis-regulatory manner.

Download PDF

Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.mov format). Morphology of hPSCs upon soft substrate.
  • Movie S2 (.mov format). Morphology of hPSCs upon hard substrate.
  • Movie S3 (.mov format). Morphology of hPSCs upon TCPS.

Files in this Data Supplement: