Science Advances

Supplementary Materials

This PDF file includes:

  • Supplementary Materials and Methods
  • Scheme S1. Preparation and tumor-targeted delivery of dual pH-sensitive nanodrug.
  • Fig. S1. The synthetic route and 1H NMR spectra of copolymers.
  • Fig. S2. Characterizations of copolymers, antibody, and nanomicelle.
  • Fig. S3. T cell binding and cellular uptake of nanodrug at pH 6.5.
  • Fig. S4. Cytotoxicities of nanomicelles and concentrations of CUR in tumor tissue.
  • Fig. S5. PD-1+ T cell binding of NR@PPC–aPD-1 in vivo.
  • Fig. S6. T1WI signal intensities of tumors and T1WI of the B16F10 tumor-bearing mice.
  • Fig. S7. CLSM images showing the colocalization of aPD-1 and PD-1 and intratumor distribution of nanodrug.
  • Fig. S8. In vivo immune response regulated by nanodrug.
  • Fig. S9. Schedule of in vivo study and biosafety of nanodrug.
  • Table S1. Molecular weight of the synthesized polymers.
  • Table S2. Sequences for forward and reverse specific primers for real-time reverse transcription PCR amplification.
  • References (3640)

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