Science Advances

Supplementary Materials

The PDFset includes:

  • Fig. S1. Characterization of NPs.
  • Fig. S2. Schematic illustration and detection of HPEGC of LNS.
  • Fig. S3. Distribution of logarithmic effective diffusivities for NPs with various PEG degrees at a time scale of 1 s.
  • Fig. S4. Additional in vitro data.
  • Fig. S5. Superiority of GMNP for oral delivery.
  • Fig. S6. Superior tumor permeation of GMNP compared with the NR-2%PEG and the NR-6%PEG.
  • Fig. S7. Mechanistic studies.
  • Fig. S8. Protein corona-related and biodistribution studies.
  • Fig. S9. The molecular models used in the CGMD simulation.
  • Fig. S10. Diffusion and internalization simulations.

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.avi format). Diffusion pattern of GMNP in the mucus detected by STED.
  • Movie S2 (.avi format). Diffusion pattern of SNS in the mucus detected by STED.
  • Movie S3 (.avi format). Diffusion pattern of LNS in the mucus detected by STED.
  • Movie S4 (.avi format). Diffusion pattern of NR-2%PEG in the mucus detected by STED.
  • Movie S5 (.avi format). Diffusion pattern of NR-6%PEG in the mucus detected by STED.
  • Movie S6 (.gif format). Simulation of NR with anisotropic PEG density diffusing in biological hydrogels.

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