Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. Activation of LATS induces phosphorylation of CTCF and YAP.
  • Fig. S2. Phosphorylation-mimicking mutations impair CTCF DNA binding.
  • Fig. S3. CUT&RUN-seq analysis of CTCF genomic binding under stress.
  • Fig. S4. Glucose starvation inhibits YAP target gene expression.
  • Fig. S5. Glucose starvation reduces CTCF binding preferentially at the anchors of CTCF-associated chromatin loops containing YAP target genes (BCL2L1, GLI2, LATS2, and TEAD4).
  • Fig. S6. Cellular stress down-regulates YAP target genes.
  • Fig. S7. CTCF is required to sustain YAP target gene expression.
  • Fig. S8. LATS and YAP are required for energy stress–induced loss of CTCF DNA binding at GLI2.
  • Fig. S9. Cellular stress does not perturb CTCF-anchored chromatin looping at the VEGFA locus.
  • Table S1. Genomic sites showing decreased CTCF binding under stress.

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