Science Advances

Supplementary Materials

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  • Fig. S1. MSN regulates breast cancer progression.
  • Fig. S2. Effects of MSN in regulating breast cancer are dependent on its T558 phosphorylation.
  • Fig. S3. MSN can interact with NONO and enter the nucleus with the assistance of NONO.
  • Fig. S4. The interaction between MSN and NONO is critical for MSN function on breast tumor progression.
  • Fig. S5. The function of MSN was mediated by phosphorylation of CREB.
  • Fig. S6. MSN-NONO interaction enhanced CREB signaling pathway.
  • Fig. S7. MSN-NONO interaction promoted CREB phosphorylation by facilitating the nuclear localization of pPKCĪ¶.
  • Fig. S8. There was no significant difference in the expression of EZR and RDX in different subtypes of breast cancer cell lines.
  • Fig. S9. MSN-NONO complex and downstream CREB signaling pathway could be targeted for TNBC.
  • Fig. S10. Uncropped images from Western blots.

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