Science Advances

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• Fig. S1. XBP1 splicing and IRE1α endonuclease activity are not involved in UPS of ΔF508-CFTR (control experiments of Fig. 1).
• Fig. S2. IRE1α kinase–ASK1 pathway is required for UPS of ΔF508-CFTR (control experiments of Fig. 2).
• Fig. S3. Depletion of ASK1 inhibits Arf1-Q71L–induced UPS of CFTR.
• Fig. S4. CSTMP stimulates the cell surface expression of ΔF508-CFTR by activating IRE1α kinase.
• Fig. S5. CSTMP induces the cell surface expression of ΔF508-CFTR via UPS.
• Fig. S6. CSTMP (10 μM) does not evoke apoptotic signal.
• Fig. S7. CSTMP induces the cell surface expression of ΔF508-CFTR without evoking cellular apoptosis.
• Fig. S8. Measurements of CFTR Cl⁻ channel activity (control experiments of Fig. 4, C to F).
• Fig. S9. CSTMP induces the cell surface expression of p.H723R-pendrin via UPS.
• Fig. S10. The LD₅₀ value of CSTMP in mice (per os) is 25.9 mg/kg per day.

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