Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. UV-vis characterization.
  • Fig. S2. Thermal relaxation.
  • Fig. S3. Viability of RS4;11 acute lymphoblastic leukemia cells after treatment with PHOTAC-I for 72 hours in the dark or under pulsed (100 ms every 10 s) 390-nm irradiation.
  • Fig. S4. Immunoblot analysis of PHOTAC-I-3.
  • Fig. S5. Immunoblot analysis of BRD4 after treatment of RS4;11 cells with PHOTACs.
  • Fig. S6. Model of the photoswitch-cereblon interaction.
  • Fig. S7. CRBN knockdown control.
  • Fig. S8. Me-PHOTAC-I-3 control.
  • Fig. S9. FKBP12 Immunoblots in RS4;11 cells.
  • Fig. S10. Immunoblot analysis of FKBP12 after treatment of RS4;11 cells.
  • General information
  • Synthetic Procedures and Characterization
  • References (6064)

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