Science Advances

Supplementary Materials

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  • Fig. S1. The schematic illustration of the synthesis of opto-pomalidomide and the working model for opto-pomalidomide to achieve light-induced degradation of IKZF1/3.
  • Fig. S2. UPLC-MS characterization and the time-dependent uncaging of pomalidomide and opto-pomalidomide.
  • Fig. S3. Uncaging of opto-pomalidomide by UVA irradiation leads to active degradation of IKZFs in multiple myeloma cancer cell lines.
  • Fig. S4. The schematic illustration of the synthesis of opto-dBET1 and the working model for opto-dBET1 to achieve light-induced degradation of BRDs.
  • Fig. S5. UPLC-MS characterization and the time-dependent uncaging of opto-dBET1 by UVA irradiation in vitro.
  • Fig. S6. dBET1 inhibits cell proliferation in a CRBN-dependent manner.
  • Fig. S7. The schematic illustration of the synthesis of opto-dALK and the working model for opto-dALK to achieve light-induced degradation of ALK fusion proteins.
  • Fig. S8. UPLC-MS characterization and the time-dependent uncaging process of opto-dALK.
  • Fig. S9. Dose-dependent degradation of ALK fusion proteins by dALK.

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