Science Advances

This PDF file includes:

• Supplementary Materials and Methods
• Computations and results
• Fig. S1. Local isotopy and crossing change.
• Fig. S2. The network of knot diagrams.
• Fig. S3. Grid diagrams.
• Fig. S4. Side-by-side comparison of circos plots in the 2D and 3D models.
• Fig. S5. The knot reduction factor increases with the tightness of hooked juxtapositions.
• References (38, 39)

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