Science Advances

Supplementary Materials

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  • Supplementary Materials and Methods
  • Fig. S1. Complexity of a formulation does not significantly impact elongation of thin films.
  • Fig. S2. Tensile strength of thin films is influenced by certain excipient combinations.
  • Fig. S3. Viable adenovirus can be recovered from films reconstituted with a variety of diluents.
  • Fig. S4. Virus, excipients, and solvent volume significantly affect viscosity of solutions made from reconstituted films.
  • Fig. S5. Adenovirus stability profiles of rehydrated and solid films at elevated temperatures.
  • Fig. S6. Recovery of live adenovirus from the film matrix at elevated temperature is significantly affected by environmental humidity.
  • Fig. S7. DSC analysis reveals that thin films are amorphous solids across a wide temperature range.
  • Fig. S8. X-ray scanning diffraction reveals films as amorphous solids.
  • Fig. S9. Cytotoxicity profile of thin film vaccine validates safety of dosage form.
  • Fig. S10. Virus is evenly distributed throughout the film matrix.
  • Fig. S11. The amount of virus embedded in film matrix does not affect recovery of virus from the film matrix.
  • Table S1. Summary of formulations.

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