Science Advances

Supplementary Materials

This PDF file includes:

  • Note S1. The ordinary differential equations for integrin clustering, cluster disassembly, and FAKY397 activation.
  • Note S2. Assumptions.
  • Note S3. Limitations and potential problems.
  • Note S4. Quantified relationship between substrate stiffness and FAKY397 phosphorylation.
  • Table S1. The plasma membrane events and transition rates.
  • Table S2. Baseline model parameters.
  • Table S3. Conservation equations.
  • Table S4. Equations describing integrin activation and clustering and FAK-Src interactions.
  • Table S5. Equations describing negative feedback regulation.
  • Fig. S1. Negative feedback ODE model.
  • Fig. S2. Cell-spreading experiments.
  • Fig. S3. The effect of substrate viscosity on the integrin cluster lifetime.
  • Fig. S4. The comparison of Odde’s and our model.
  • Fig. S5. Sliding assumption of intact FA.

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