Science Advances

Supplementary Materials

The PDF file includes:

  • Fig. S1. Differential recruitment of the PRC2 catalytic subunit Ezh2 across cell cycle.
  • Fig. S2. Cell cycle–dependent regulation of Jarid2.
  • Fig. S3. Binding of EPOP and EloB to bivalent promoters is regulated across cell cycle.
  • Fig. S4. Transcriptional activity at PRC2 target genes is attenuated during S and G2-M phases.
  • Fig. S5. Cell cycle–regulated PRC2 targets are enriched in developmental transcription factors.
  • Fig. S6. PRC2 target promoters that are regulated across cell cycle display higher levels of PRC2 binding.
  • Fig. S7. Jarid2 −/− mESCs display abnormal regulation of H3K27me3, Ser5-RNAPII, and RNA synthesis during S phase of the cell cycle.

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Purity check of cell cycle–sorted mESCs used in ChIP-seq experiments.
  • Table S2 (Microsoft Excel format). Analysis of peaks detected in ChIP-seq experiments.
  • Table S3 (Microsoft Excel format). List of genes used in this manuscript.
  • Table S4 (Microsoft Excel format). ChIP-seq enrichment and 4sU-seq expression values of HC bivalent genes.
  • Table S5 (Microsoft Excel format). Table listing reagents and published datasets used in this manuscript.

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