Science Advances

Supplementary Materials

This PDF file includes:

  • Supplementary Materials and Methods
  • Fig. S1. Asteroid plot for TadA*7.10-ssDNA.
  • Fig. S2. Comparison of the structural flexibility of the TadA monomer with TadA dimer.
  • Fig. S3. Percentage contact and the fractional H-bonding between the three nucleotides and the first interaction shell amino acids.
  • Fig. S4. Asteroid plot for TadA*0.1-ssDNA complex.
  • Fig. S5. Mutations lead to an increase in TadA* binding to the ssDNA (AAG).
  • Fig. S6. Structural importance of Ala106Val mutation.
  • Fig. S7. PMF of the TadA*-ssDNA complexes calculated using steered MD simulations.
  • Fig. S8. Comparison of the structural flexibility of the ecTadA with hAPOBEC3A.
  • Fig. S9. Modeling of TadA*-ssDNA.
  • Fig. S10. Umbrella sampling data and biased statistics.
  • Table S1. Comparison of RMSD of the representative clusters.
  • Table S2. Summary of the systems modeled and the types of simulations conducted in this study.
  • Table S3. DNA sequences used for simulations and in mammalian tissue culture experiments.
  • Table S4. First round genomic DNA PCR sequences.
  • Supplementary sequences

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