Science Advances

This PDF file includes:

• Supplementary Material and Methods
• Fig. S1. Compounds inhibit STAT3-dependent luciferase and covalently interact with GSH.
• Fig. S2. Whole gel images of competition experiments of Fig. 3.
• Fig. S3. Whole gel images of competition experiments of Fig. 3.
• Fig. S4. SDS-PAGE fluorescent band matches TrxR1 protein on Western blot.
• Fig. S5. CellTiter-Glo cell viability with or without selenium supplementation.
• Fig. S6. Whole blot images of Western blot replicates.
• Fig. S7. STAT-driven luciferase inhibition in Prx1 + Prx2 knockdown cells.
• Fig. S8. Catalase decreases H₂O₂ production affecting cell cytotoxicity of top DG compounds.
• Fig. S9. Compound effects on alternative transcription factors.

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