Science Advances

Supplementary Materials

This PDF file includes:

  • Supplementary Materials and Methods
  • Table S1. Clinicopathological features of 86 cases of human tongue squamous cell carcinoma.
  • Fig. S1. Induction of Mob1a/b deletion in tgMob1DKO mice by postnatal application of TAM.
  • Fig. S2. Cell-cell junction collapse and retained cell size of iMob1DKO cells and YAP1/TAZ expression and localization in tongue epithelium of tgMob1DKO, tgYap1TKO, and tgTazTKO mice.
  • Fig. S3. Effects of dasatinib, simvastatin, verteporfin, and Y-27632 on YAP1 protein expression and activation and tumor-suppressive effect of simvastatin.
  • Fig. S4. YAP1 expression in OSCC cell lines, the effect on an OSCC cell line of YAP1 depletion combined with cisplatin, and the effect of dasatinib on cell death in tgMob1DKO mice.
  • Fig. S5. YAP1 target gene expression correlates with YAP1 nuclear expression in human clinical OSCC specimens.
  • Fig. S6. Evaluation of gene knockdown and ectopic gene expression in the WSU-HN30 HNSCC cell line and activation of YAP1 by knockdown of TP53, PTEN, or FAT1.
  • Fig. S7. Activation of YAP1 target gene expression by molecules that are frequently altered in human OSCC.
  • Fig. S8. Positive correlation of ΔNp63α protein expression with YAP1 protein expression.
  • Fig. S9. Graphical abstract and microarray analysis of growth factors and receptors whose mRNAs are up-regulated in tgMob1DKO tongue epithelial cells.
  • References (40, 41)

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