Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. Characterization of the synthetic nanomaterials.
  • Fig. S2. Examination of free radical scavenging activity of the nanotherapeutics.
  • Fig. S3. N2 adsorption-desorption isotherm and pore property analysis.
  • Fig. S4. CeO2@ZIF-8 inhibits cell apoptosis and ROS overproduction induced by t-BOOH.
  • Fig. S5. Change in cell microstructure and mice body weight.
  • Fig. S6. Brain protection effects of CeO2@ZIF-8 in C57 MCAO mice.
  • Fig. S7. Fluorescence imaging and biodistribution analysis of CeO2@ZIF-8 in vivo.
  • Fig. S8. H&E staining of the heart, liver, spleen, lung, and kidney after treatment with CeO2@ZIF-8 for 3 days in MCAO mice model.
  • Fig. S9. Toxicity evaluation of CeO2@ZIF-8 in vivo.
  • Table S1. Pharmacokinetic parameters of CeO2 nanopolyhedra and CeO2@ZIF-8 composite nanomaterials.

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