Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. Schematic illustration of the establishment of a bypass in the TCA cycle by uptake of succinate resulting from the hydrolysis of degradation fragments.
  • Fig. S2. Spectrum characterization for the prepolymers synthesized in this study before cross-linking.
  • Fig. S3. Spectrum characterization for the BAM polymers after cross-linking.
  • Fig. S4. Hydrophilicity and morphology characterization of BAM.
  • Fig. S5. In vitro degradation of BAM and PLA scaffolds in PBS.
  • Fig. S6. SEM image of rMSCs.
  • Fig. S7. LC-MS analysis for the succinate content in rMSCs.
  • Fig. S8. Fluorescent images of JC-1 staining for mitochondrial membrane potential.
  • Fig. S9. Masson’s trichrome staining and SEM images of BAM and PLA scaffolds after subcutaneous implantation.
  • Fig. S10. The construction of a critical-sized segment defect in rabbit femur.
  • Fig. S11. H&E staining, SEM, and EDX elemental scanning for the analysis of bone regeneration.
  • Fig. S12. Micro-CT, histological staining, and quantitative analysis of bone repair in BAM, PLA, and CaP scaffolds.
  • Table S1. XPS quantification for RB/PLA sample retrieved from defect area.
  • Table S2. XPS quantification for RB/BAM sample retrieved from defect area.
  • Table S3. Primer sequences for Runx-2, OCN, P2X7, and IDH3 genes.

Download PDF

Files in this Data Supplement: