Science Advances

Supplementary Materials

Mathematical prediction of clinical outcomes in advanced cancer patients treated with checkpoint inhibitor immunotherapy

Joseph D. Butner, Dalia Elganainy, Charles X. Wang, Zhihui Wang, Shu-Hsia Chen, Nestor F. Esnaola, Renata Pasqualini, Wadih Arap, David S. Hong, James Welsh, Eugene J. Koay, Vittorio Cristini

Download Supplement

This PDF file includes:

  • Model Development
  • Patient Statistics
  • Blood markers are not significant indicators of patient response
  • Estimation of α0 in the literature validation cohort and sensitivity analysis
  • Pre-treatment tumor growth rate is not a significant indicator of patient response
  • Multivariate analysis reveals growth rate at first restaging (α1) is a prognostic indicator of patient response
  • Model results suggest a possible mechanism for pseudo-progression
  • Patient response look-up tables
  • Negative model parameter values
  • Figs. S1 to S6
  • Tables S1 to S5
  • References

Files in this Data Supplement: