RT Journal Article SR Electronic T1 The hijacking of a receptor kinase–driven pathway by a wheat fungal pathogen leads to disease JF Science Advances JO Sci Adv FD American Association for the Advancement of Science SP e1600822 DO 10.1126/sciadv.1600822 VO 2 IS 10 A1 Shi, Gongjun A1 Zhang, Zengcui A1 Friesen, Timothy L. A1 Raats, Dina A1 Fahima, Tzion A1 Brueggeman, Robert S. A1 Lu, Shunwen A1 Trick, Harold N. A1 Liu, Zhaohui A1 Chao, Wun A1 Frenkel, Zeev A1 Xu, Steven S. A1 Rasmussen, Jack B. A1 Faris, Justin D. YR 2016 UL http://advances.sciencemag.org/content/2/10/e1600822.abstract AB Necrotrophic pathogens live and feed on dying tissue, but their interactions with plants are not well understood compared to biotrophic pathogens. The wheat Snn1 gene confers susceptibility to strains of the necrotrophic pathogen Parastagonospora nodorum that produce the SnTox1 protein. We report the positional cloning of Snn1, a member of the wall-associated kinase class of receptors, which are known to drive pathways for biotrophic pathogen resistance. Recognition of SnTox1 by Snn1 activates programmed cell death, which allows this necrotroph to gain nutrients and sporulate. These results demonstrate that necrotrophic pathogens such as P. nodorum hijack host molecular pathways that are typically involved in resistance to biotrophic pathogens, revealing the complex nature of susceptibility and resistance in necrotrophic and biotrophic pathogen interactions with plants.