RT Journal Article
SR Electronic
T1 Organic electronics for high-resolution electrocorticography of the human brain
JF Science Advances
JO Sci Adv
FD American Association for the Advancement of Science
SP e1601027
DO 10.1126/sciadv.1601027
VO 2
IS 11
A1 Khodagholy, Dion
A1 Gelinas, Jennifer N.
A1 Zhao, Zifang
A1 Yeh, Malcolm
A1 Long, Michael
A1 Greenlee, Jeremy D.
A1 Doyle, Werner
A1 Devinsky, Orrin
A1 Buzsáki, György
YR 2016
UL http://advances.sciencemag.org/content/2/11/e1601027.abstract
AB Localizing neuronal patterns that generate pathological brain signals may assist with tissue resection and intervention strategies in patients with neurological diseases. Precise localization requires high spatiotemporal recording from populations of neurons while minimizing invasiveness and adverse events. We describe a large-scale, high-density, organic material–based, conformable neural interface device (“NeuroGrid”) capable of simultaneously recording local field potentials (LFPs) and action potentials from the cortical surface. We demonstrate the feasibility and safety of intraoperative recording with NeuroGrids in anesthetized and awake subjects. Highly localized and propagating physiological and pathological LFP patterns were recorded, and correlated neural firing provided evidence about their local generation. Application of NeuroGrids to brain disorders, such as epilepsy, may improve diagnostic precision and therapeutic outcomes while reducing complications associated with invasive electrodes conventionally used to acquire high-resolution and spiking data.